Role of Genomics and RNA-seq in Studies of Fungal Virulence

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Title: Role of Genomics and RNA-seq in Studies of Fungal Virulence
Authors: Riccombeni, Alessandro
Butler, Geraldine
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Date: Dec-2012
Online since: 2013-12-31T04:00:07Z
Abstract: Since its introduction in the last decade, massive parallel sequencing, or “next-generation sequencing”, has revolutionized our access to genomic information, providing accurate data with increasingly higher yields and lower costs with respect to first-generation technology. Massive parallel sequencing of cDNA, or RNA-seq, is progressively replacing array-based technology as the method of choice for transcriptomics. This review describes some of the most recent applications of next-generation sequencing technology to the study of pathogenic fungi, including Candida, Aspergillus and Cryptococcus species. Several integrated approaches illustrate the power and accuracy of RNA-seq for studying the biology of human fungal pathogens. In addition, the lack of consistency in data analysis is discussed.
Type of material: Journal Article
Publisher: Springer
Journal: Current Fungal Infection Reports
Volume: 6
Issue: 4
Start page: 297
End page: 274
Copyright (published version): 2012 Springer Science+Business Media
Keywords: AspergillusBioinformaticsCandidaChIP-seqCryptococcusDermatophytesGenomicsNext-generation sequencingRNA-seq
Subject LCSH: Aspergillus
Nucleotide sequence
DOI: 10.1007/s12281-012-0104-z
Language: en
Status of Item: Not peer reviewed
Appears in Collections:Biomolecular and Biomedical Science Research Collection

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