Role of Genomics and RNA-seq in Studies of Fungal Virulence
|Title:||Role of Genomics and RNA-seq in Studies of Fungal Virulence||Authors:||Riccombeni, Alessandro
|Permanent link:||http://hdl.handle.net/10197/3934||Date:||Sep-2012||Abstract:||Since its introduction in the last decade, massive parallel sequencing, or "next-generation sequencing", has revolutionized our access to genomic information, providing accurate data with increasingly higher yields and lower costs with respect to first-generation technology. Massive parallel sequencing of cDNA, or RNA-seq, is progressively replacing array-based technology as the method of choice for transcriptomics. This review describes some of the most recent applications of next-generation sequencing technology to the study of pathogenic fungi, including Candida, Aspergillus and Cryptococcusspecies. Several integrated approaches illustrate the power and accuracy of RNA-seq for studying the biology of human fungal pathogens. In addition, the lack of consistency in data analysis is discussed.||Type of material:||Journal Article||Publisher:||Springer||Copyright (published version):||2012 Springer Science+Business Media||Keywords:||Aspergillus;Bioinformatics;Candida;ChIP-seq;Cryptococcus;Dermatophytes;Genomics;Next-generation sequencing;RNA-seq||Subject LCSH:||Nucleotide sequence
|DOI:||10.1007/s12281-012-0104-z||Language:||en||Status of Item:||Not peer reviewed|
|Appears in Collections:||Medicine Research Collection|
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