Role of Genomics and RNA-seq in Studies of Fungal Virulence

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Title: Role of Genomics and RNA-seq in Studies of Fungal Virulence
Authors: Riccombeni, Alessandro
Butler, Geraldine
Permanent link: http://hdl.handle.net/10197/3934
Date: Sep-2012
Abstract: Since its introduction in the last decade, massive parallel sequencing, or "next-generation sequencing", has revolutionized our access to genomic information, providing accurate data with increasingly higher yields and lower costs with respect to first-generation technology. Massive parallel sequencing of cDNA, or RNA-seq, is progressively replacing array-based technology as the method of choice for transcriptomics. This review describes some of the most recent applications of next-generation sequencing technology to the study of pathogenic fungi, including Candida, Aspergillus and Cryptococcusspecies. Several integrated approaches illustrate the power and accuracy of RNA-seq for studying the biology of human fungal pathogens. In addition, the lack of consistency in data analysis is discussed.
Type of material: Journal Article
Publisher: Springer
Copyright (published version): 2012 Springer Science+Business Media
Keywords: Aspergillus;Bioinformatics;Candida;ChIP-seq;Cryptococcus;Dermatophytes;Genomics;Next-generation sequencing;RNA-seq
Subject LCSH: Nucleotide sequence
Genomics
Bioinformatics
Aspergillus
Candida
Cryptococcus
Dermatophytes
DOI: 10.1007/s12281-012-0104-z
Language: en
Status of Item: Not peer reviewed
Appears in Collections:Medicine Research Collection

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