ELM--the database of eukaryotic linear motifs

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Title: ELM--the database of eukaryotic linear motifs
Authors: Dinkel, Holger
Michael, Sushama
Weatheritt, Robert J.
Davey, Norman E.
Van Roey, Kim
Altenberg, Brigitte
Toedt, Grischa
Uyar, Bora
Seiler, Markus
Budd, Aidan
Jödicke, Lisa
Dammert, Marcel A.
Schroeter, Christian
Hammer, Maria
Schmidt, Tobias
Jehl, Peter
McGuigan, Caroline
Dymecka, Magdalena
Chica, Claudia
Luck, Katja
Via, Allegra
Chatr-aryamontri, Andrew
Haslam, Niall J.
Grebnev, Gleb
Edwards, Richard J.
Steinmetz, Michel O.
Meiselbach, Heike
Diella, Francesca
Gibson, Toby J.
Permanent link: http://hdl.handle.net/10197/3943
Date: Jan-2012
Abstract: Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspect of the regulatory functionality of the cell. They are particularly prominent in mediating cell signaling, controlling protein turnover and directing protein localization. Given their importance, our understanding of motifs is surprisingly limited, largely as a result of the difficulty of discovery, both experimentally and computationally. The Eukaryotic Linear Motif (ELM) resource at http://elm.eu.org provides the biological community with a comprehensive database of known experimentally validated motifs, and an exploratory tool to discover putative linear motifs in user-submitted protein sequences. The current update of the ELM database comprises 1800 annotated motif instances representing 170 distinct functional classes, including approximately 500 novel instances and 24 novel classes. Several older motif class entries have been also revisited, improving annotation and adding novel instances. Furthermore, addition of full-text search capabilities, an enhanced interface and simplified batch download has improved the overall accessibility of the ELM data. The motif discovery portion of the ELM resource has added conservation, and structural attributes have been incorporated to aid users to discriminate biologically relevant motifs from stochastically occurring non-functional instances.
Type of material: Journal Article
Publisher: OUP
Journal: Nucleic Acids Research
Volume: 40
Issue: Database Issue 1
Start page: 1
End page: 51
Copyright (published version): 2011 The Author(s)
Subject LCSH: Amino acid sequence--Databases
DOI: 10.1093/nar/gkr1064
Language: en
Status of Item: Peer reviewed
Appears in Collections:Medicine Research Collection

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