Expression of genes for bone morphogenetic proteins BMP-2, BMP-4 and BMP-6 in various parts of the human skeleton

DC FieldValueLanguage
dc.contributor.authorKochanowska, Iwona
dc.contributor.authorChaberek, Slawomir
dc.contributor.authorWojtowicz, Andrzej
dc.contributor.authorMarczynski, Bartosz
dc.contributor.authorWłodarski, Krzysztof
dc.contributor.authorDytko, Malgorzata
dc.contributor.authorOstrowski, Kazimierz
dc.date.accessioned2013-01-11T17:19:18Z
dc.date.available2013-01-11T17:19:18Z
dc.date.copyright2007 Kochanowska et alen
dc.date.issued2007-12-27
dc.identifier.citationBMC Musculoskeletal Disordersen
dc.identifier.urihttp://hdl.handle.net/10197/4016
dc.description.abstractBACKGROUND: Differences in duration of bone healing in various parts of the human skeleton are common experience for orthopaedic surgeons. The reason for these differences is not obvious and not clear.METHODS: In this paper we decided to measure by the use of real-time RT-PCR technique the level of expression of genes for some isoforms of bone morphogenetic proteins (BMPs), whose role is proven in bone formation, bone induction and bone turnover. Seven bone samples recovered from various parts of skeletons from six cadavers of young healthy men who died in traffic accidents were collected. Activity of genes for BMP-2, -4 and -6 was measured by the use of fluorescent SYBR Green I.RESULTS: It was found that expression of m-RNA for BMP-2 and BMP-4 is higher in trabecular bone in epiphyses of long bones, cranial flat bones and corpus mandibulae then in the compact bone of diaphyses of long bones. In all samples examined the expression of m-RNA for BMP-4 was higher than for BMP-2.CONCLUSION: It was shown that m-RNA for BMP-6 is not expressed in the collected samples at all. It is postulated that differences in the level of activation of genes for BMPs is one of the important factors which determine the differences in duration of bone healing of various parts of the human skeleton.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.subjectBone morphogenetic proteinsen
dc.subjectGene expressionen
dc.titleExpression of genes for bone morphogenetic proteins BMP-2, BMP-4 and BMP-6 in various parts of the human skeletonen
dc.typeJournal Articleen
dc.internal.authorcontactothermalgorzata.milewska@ucd.ie
dc.internal.availabilityFull text availableen
dc.statusPeer revieweden
dc.identifier.volume8en
dc.identifier.issue128en
dc.identifier.doi10.1186/1471-2474-8-128-
dc.neeo.contributorKochanowska|Iwona|aut|-
dc.neeo.contributorChaberek|Slawomir|aut|-
dc.neeo.contributorWojtowicz|Andrzej|aut|-
dc.neeo.contributorMarczynski|Bartosz|aut|-
dc.neeo.contributorWłodarski|Krzysztof|aut|-
dc.neeo.contributorDytko|Malgorzata|aut|-
dc.neeo.contributorOstrowski|Kazimierz|aut|-
dc.description.adminAuthor has checked copyrighten
dc.description.adminDG 16/11/12en
dc.internal.rmsid317997875
dc.date.updated2012-11-15T19:44:38Z
item.fulltextWith Fulltext-
item.grantfulltextopen-
Appears in Collections:Conway Institute Research Collection
Files in This Item:
File Description SizeFormat 
BMC_Muscoskeletal_Disorders_2007.pdf705.6 kBAdobe PDFDownload
Show simple item record

SCOPUSTM   
Citations 10

30
Last Week
0
Last month
checked on Sep 11, 2020

Page view(s)

1,074
Last Week
2
Last month
checked on Nov 24, 2020

Download(s)

180
checked on Nov 24, 2020

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.