Targeting tumour necrosis factor-α in hypoxia and synaptic signalling

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Title: Targeting tumour necrosis factor-α in hypoxia and synaptic signalling
Authors: O'Connor, J. J.
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Date: Jan-2013
Online since: 2014-01-31T04:00:08Z
Abstract: Tumour necrosis factor (TNF)-α is a pro-inflammatory cytokine, which is synthesised and released in the brain by astrocytes, microglia and neurons in response to numerous internal and external stimuli. It is involved in many physiological and pathophysiological processes such as gene transcription, cell proliferation, apoptosis, synaptic signalling and neuroprotection. The complex actions of TNF-α in the brain are under intense investigation. TNF-α has the ability to induce selective necrosis of some cells whilst sparing others and this has led researchers to discover multiple activated signalling cascades. In many human diseases including acute stroke and inflammation and those involving hypoxia, levels of TNF-α are increased throughout different brain regions. TNF-α signalling may also have several positive and negative effects on neuronal function including glutamatergic synaptic transmission and plasticity. Exogenous TNF-α may also exacerbate the neuronal response to hypoxia. This review will summarise the actions of TNF-α in the central nervous system on synaptic signalling and its effects during hypoxia.
Type of material: Journal Article
Publisher: Springer-Verlag
Journal: Irish Journal of Medical Science
Issue: January 2013
Copyright (published version): Royal Academy of Medicine in Ireland 2013
Keywords: TNF-αHypoxiaProlyl hydroxylaseHippocampusSynaptic transmissionSynaptic plasticityInflammation
DOI: 10.1007/s11845-013-0911-4
Language: en
Status of Item: Not peer reviewed
Appears in Collections:Conway Institute Research Collection
Biomolecular and Biomedical Science Research Collection

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