Targeting tumour necrosis factor-α in hypoxia and synaptic signalling

DC FieldValueLanguage
dc.contributor.authorO'Connor, J. J.-
dc.date.accessioned2013-02-22T10:08:59Z-
dc.date.available2014-01-31T04:00:08Z-
dc.date.copyrightRoyal Academy of Medicine in Ireland 2013en
dc.date.issued2013-01-
dc.identifier.citationIrish Journal of Medical Scienceen
dc.identifier.issn0021-1265-
dc.identifier.issn1863-4362-
dc.identifier.urihttp://hdl.handle.net/10197/4133-
dc.description.abstractTumour necrosis factor (TNF)-α is a pro-inflammatory cytokine, which is synthesised and released in the brain by astrocytes, microglia and neurons in response to numerous internal and external stimuli. It is involved in many physiological and pathophysiological processes such as gene transcription, cell proliferation, apoptosis, synaptic signalling and neuroprotection. The complex actions of TNF-α in the brain are under intense investigation. TNF-α has the ability to induce selective necrosis of some cells whilst sparing others and this has led researchers to discover multiple activated signalling cascades. In many human diseases including acute stroke and inflammation and those involving hypoxia, levels of TNF-α are increased throughout different brain regions. TNF-α signalling may also have several positive and negative effects on neuronal function including glutamatergic synaptic transmission and plasticity. Exogenous TNF-α may also exacerbate the neuronal response to hypoxia. This review will summarise the actions of TNF-α in the central nervous system on synaptic signalling and its effects during hypoxia.en
dc.language.isoenen
dc.publisherSpringer-Verlagen
dc.rightsThe final publication is available at www.springerlink.comen
dc.subjectTNF-αen
dc.subjectHypoxiaen
dc.subjectProlyl hydroxylaseen
dc.subjectHippocampusen
dc.subjectSynaptic transmissionen
dc.subjectSynaptic plasticityen
dc.subjectInflammationen
dc.titleTargeting tumour necrosis factor-α in hypoxia and synaptic signallingen
dc.typeJournal Articleen
dc.internal.authorcontactotherjohn.oconnor@ucd.ie-
dc.internal.availabilityFull text availableen
dc.statusNot peer revieweden
dc.identifier.issueJanuary 2013en
dc.identifier.doi10.1007/s11845-013-0911-4-
dc.neeo.contributorO'Connor|J. J.|aut|-
dc.description.adminAS 15-2-13en
dc.internal.rmsid315293849-
dc.date.updated2013-01-10T09:30:51Z-
item.grantfulltextopen-
item.fulltextWith Fulltext-
Appears in Collections:Conway Institute Research Collection
Biomolecular and Biomedical Science Research Collection
Files in This Item:
File Description SizeFormat 
IJMS_Review_JOC.pdf275.52 kBAdobe PDFDownload
Show simple item record

SCOPUSTM   
Citations 10

23
Last Week
0
Last month
checked on Aug 17, 2018

Page view(s) 20

161
checked on May 25, 2018

Download(s) 50

134
checked on May 25, 2018

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.