Options
Note : Network random walk model of two-state protein folding : Test of the theory
Date Issued
2013-01-18
Date Available
2013-03-14T15:02:20Z
Abstract
We study two-state protein folding in the framework of a toy model of protein dynamics. This model has an important advantage: it allows for an analytical solution for the sum of folding and unfolding rate constants [A. M. Berezhkovskii, F. Tofoleanu, and N.-V. Buchete, J. Chem. Theory Comput. 7, 2370 (2011)10.1021/ct200281d] and hence for the reactive flux at equilibrium. We use the model to test the Kramers-type formula for the reactive flux, which was derived assuming that the protein dynamics is described by a Markov random walk on a network of complex connectivity [A. Berezhkovskii, G. Hummer, and A. Szabo, J. Chem. Phys. 130, 205102 (2009)10.1063/1.3139063]. It is shown that the Kramers-type formula leads to the same result for the reactive flux as the sum of the rate constants.
Type of Material
Journal Article
Publisher
AIP
Journal
The Journal of chemical physics
Volume
138
Issue
3
Start Page
036101
End Page
036101
Copyright (Published Version)
2013, American Institute of Physics
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
File(s)
No Thumbnail Available
Name
berezhkovskii.murphy.buchete.2013.JCP.2state.pdf
Size
289.67 KB
Format
Owning collection
Scopus© citations
5
Acquisition Date
Mar 28, 2024
Mar 28, 2024
Views
1846
Acquisition Date
Mar 28, 2024
Mar 28, 2024
Downloads
381
Last Month
3
3
Acquisition Date
Mar 28, 2024
Mar 28, 2024