Influence of Surface Groups on Poly(propylene imine) Dendrimers Antiprion Activity
|Title:||Influence of Surface Groups on Poly(propylene imine) Dendrimers Antiprion Activity||Authors:||McCarthy, James M.
Moreno, Beatriz Rasines
Rogers, Mark S.
|Permanent link:||http://hdl.handle.net/10197/4251||Date:||12-Dec-2012||Online since:||2013-04-15T13:35:18Z||Abstract:||Prion diseases are characterized by the accumulation of PrP(Sc), an aberrantly folded isoform of the host protein PrP(C). Specific forms of synthetic molecules known as dendrimers are able to eliminate protease-resistant PrP(Sc) in both an intracellular and in vitro setting. The properties of a dendrimer which govern this ability are unknown. We addressed the issue by comparing the in vitro antiprion ability of numerous modified poly(propylene-imine) dendrimers, which varied in size, structure, charge, and surface group composition. Several of the modified dendrimers, including an anionic glycodendrimer, reduced the level of protease resistant PrP(Sc) in a prion strain-dependent manner. This led to the formulation of a new working model for dendrimer/prion interactions which proposes dendrimers eliminate PrP(Sc) by destabilizing the protein and rendering it susceptible to proteolysis. This ability is not dependent on any particular charge of dendrimer, but does require a high density of reactive surface groups.||Type of material:||Journal Article||Publisher:||American Chemical Society||Journal:||Biomacromolecules||Volume:||14||Issue:||1||Start page:||27||End page:||37||Copyright (published version):||2012, American Chemical Society||Keywords:||Dendrimers; PrPSc; Prions||DOI:||10.1021/bm301165u||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Biology & Environmental Science Research Collection|
Show full item record
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.