Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species

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Title: Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species
Authors: Amadio, Jessica
Murphy, Cormac D.
Permanent link: http://hdl.handle.net/10197/4302
Date: 1-Feb-2011
Abstract: Fungi belonging to the genus Cunninghamella have enzymes similar to those employed by mammals for the detoxification of xenobiotics, thus they are useful as models of mammalian drug metabolism, and as a source for drug metabolites. We report the transformation of the anti-cancer drug flutamide in Cunninghamella sp. The most predominant phase I metabolites present in the plasma of humans, 2-hydroxyflutamide and 4-nitro-3-(trifluoromethyl)aniline, were also produced in Cunninghamella cultures. Other phase I and phase II metabolites were also detected using a combination of HPLC, GC–MS and 19F-NMR.
Type of material: Journal Article
Publisher: Springer Netherlands
Copyright (published version): 2011, Springer Netherlands
Keywords: Biotransformation;Cytochrome P450;Fluorine-19 NMR;Sulfotransferase
DOI: 10.1007/s10529-010-0425-3
Language: en
Status of Item: Not peer reviewed
Appears in Collections:Biomolecular and Biomedical Science Research Collection

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