Incandescent Porous Carbon Microspheres to Light up Cells: Solution Phenomena and Cellular Uptake

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Title: Incandescent Porous Carbon Microspheres to Light up Cells: Solution Phenomena and Cellular Uptake
Authors: Duffy, Paul
Magno, Luís M.
Yadavc, Rahul B.
Roberts, Selene K.
Ward, Andrew D.
Botchway, Stanley W.
Colavita, Paula E.
Quinn, Susan J.
Permanent link: http://hdl.handle.net/10197/4320
Date: 2012
Abstract: Carbon based materials are attractive for biological applications because of their excellent biocompatibility profile. Porous carbons with high specific surface area are particularly interesting because it is possible in principle to leverage their properties to deliver high drug payloads. In this work, porous carbon microspheres with high specific surface area were prepared and studied in solution and in cells. Raman optical tweezer trapping of microspheres, excited by 532 nm, results in graphitization and incandescence in solvents that display poor heat conduction. Fluorescence confocal microscopy imaging was used to demonstrate the uptake of fluorescently labelled microspheres by cells and the ability to leverage their optical absorptivity in order to cause carbon graphitization and cell death.
Funding Details: Science Foundation Ireland
Type of material: Journal Article
Publisher: RSC Publishing
Copyright (published version): 2012, Royal Society of Chemistry
Keywords: Intracellular delivery agents;Raman-optical tweezer studies;Incandescent emission;Graphitization
DOI: 10.1039/C1JM14303D
Language: en
Status of Item: Not peer reviewed
Appears in Collections:Chemistry Research Collection

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