Incandescent Porous Carbon Microspheres to Light up Cells: Solution Phenomena and Cellular Uptake
|Title:||Incandescent Porous Carbon Microspheres to Light up Cells: Solution Phenomena and Cellular Uptake||Authors:||Duffy, Paul; Magno, Luís M.; Yadavc, Rahul B.; Roberts, Selene K.; Ward, Andrew D.; Botchway, Stanley W.; Colavita, Paula E.; Quinn, Susan J.||Permanent link:||http://hdl.handle.net/10197/4320||Date:||2012||Online since:||2013-05-16T09:09:06Z||Abstract:||Carbon based materials are attractive for biological applications because of their excellent biocompatibility profile. Porous carbons with high specific surface area are particularly interesting because it is possible in principle to leverage their properties to deliver high drug payloads. In this work, porous carbon microspheres with high specific surface area were prepared and studied in solution and in cells. Raman optical tweezer trapping of microspheres, excited by 532 nm, results in graphitization and incandescence in solvents that display poor heat conduction. Fluorescence confocal microscopy imaging was used to demonstrate the uptake of fluorescently labelled microspheres by cells and the ability to leverage their optical absorptivity in order to cause carbon graphitization and cell death.||Funding Details:||Science Foundation Ireland||Funding Details:||EPA Ireland||Type of material:||Journal Article||Publisher:||RSC Publishing||Journal:||Journal of Materials Chemistry||Volume:||22||Issue:||2||Start page:||432||End page:||439||Copyright (published version):||2012, Royal Society of Chemistry||Keywords:||Intracellular delivery agents; Raman-optical tweezer studies; Incandescent emission; Graphitization||DOI:||10.1039/C1JM14303D||Language:||en||Status of Item:||Not peer reviewed||This item is made available under a Creative Commons License:||https://creativecommons.org/licenses/by-nc-nd/3.0/ie/|
|Appears in Collections:||Chemistry Research Collection|
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