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Incandescent Porous Carbon Microspheres to Light up Cells: Solution Phenomena and Cellular Uptake
Date Issued
2012
Date Available
2013-05-16T09:09:06Z
Abstract
Carbon based materials are attractive for biological applications because of their excellent biocompatibility profile. Porous carbons with high specific surface area are particularly interesting because it is possible in principle to leverage their properties to deliver high drug payloads. In this work, porous carbon microspheres with high specific surface area were prepared and studied in solution and in cells. Raman optical tweezer trapping of microspheres, excited by 532 nm, results in graphitization and incandescence in solvents that display poor heat conduction. Fluorescence confocal microscopy imaging was used to demonstrate the uptake of fluorescently labelled microspheres by cells and the ability to leverage their optical absorptivity in order to cause carbon graphitization and cell death.
Sponsorship
Science Foundation Ireland
Other Sponsorship
EPA Ireland
Type of Material
Journal Article
Publisher
RSC Publishing
Journal
Journal of Materials Chemistry
Volume
22
Issue
2
Start Page
432
End Page
439
Copyright (Published Version)
2012, Royal Society of Chemistry
Language
English
Status of Item
Not peer reviewed
This item is made available under a Creative Commons License
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