Incandescent Porous Carbon Microspheres to Light up Cells: Solution Phenomena and Cellular Uptake

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Title: Incandescent Porous Carbon Microspheres to Light up Cells: Solution Phenomena and Cellular Uptake
Authors: Duffy, PaulMagno, Luís M.Yadavc, Rahul B.Roberts, Selene K.Ward, Andrew D.Botchway, Stanley W.Colavita, Paula E.Quinn, Susan J.
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Date: 2012
Online since: 2013-05-16T09:09:06Z
Abstract: Carbon based materials are attractive for biological applications because of their excellent biocompatibility profile. Porous carbons with high specific surface area are particularly interesting because it is possible in principle to leverage their properties to deliver high drug payloads. In this work, porous carbon microspheres with high specific surface area were prepared and studied in solution and in cells. Raman optical tweezer trapping of microspheres, excited by 532 nm, results in graphitization and incandescence in solvents that display poor heat conduction. Fluorescence confocal microscopy imaging was used to demonstrate the uptake of fluorescently labelled microspheres by cells and the ability to leverage their optical absorptivity in order to cause carbon graphitization and cell death.
Funding Details: Science Foundation Ireland
Funding Details: EPA Ireland
Type of material: Journal Article
Publisher: RSC Publishing
Journal: Journal of Materials Chemistry
Volume: 22
Issue: 2
Start page: 432
End page: 439
Copyright (published version): 2012, Royal Society of Chemistry
Keywords: Intracellular delivery agentsRaman-optical tweezer studiesIncandescent emissionGraphitization
DOI: 10.1039/C1JM14303D
Language: en
Status of Item: Not peer reviewed
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Appears in Collections:Chemistry Research Collection

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