A comparative picosecond transient infrared study of 1-methylcytosine and 5'-dCMP that sheds further light on the excited states of cytosine derivatives

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Title: A comparative picosecond transient infrared study of 1-methylcytosine and 5'-dCMP that sheds further light on the excited states of cytosine derivatives
Authors: Keane, Páraic M.
Wojdyla, Michal
Doorley, Gerard W.
Watson, Graeme W.
Clark, Ian P.
Greetham, Gregory M.
Parker, Anthony W.
Towrie, Michael
Kelly, John M.
Quinn, Susan J.
Permanent link: http://hdl.handle.net/10197/4323
Date: Mar-2011
Online since: 2013-05-16T09:22:07Z
Abstract: The role of N1-substitution in controlling the deactivation processes in photoexcited cytosine derivatives has been explored using picosecond time-resolved IR spectroscopy. The simplest N1-substituted derivative, 1-methylcytosine, exhibits relaxation dynamics similar to the cytosine nucleobase and distinct from the biologically relevant nucleotide and nucleoside analogues, which have longer-lived excited-state intermediates. It is suggested that this is the case because the sugar group either facilitates access to the long-lived (1)n(O)Ï * state or retards its crossover to the ground state.
Type of material: Journal Article
Publisher: ACS Publications
Journal: Journal of the American Chemical Society
Volume: 133
Issue: 12
Start page: 4212
End page: 4215
Copyright (published version): 2011 American Chemical Society
Keywords: Cytosine derivatives1-methylcytosineInfrared spectroscopy
DOI: 10.1021/ja1106089
Language: en
Status of Item: Peer reviewed
Appears in Collections:Chemistry Research Collection

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