A comparative picosecond transient infrared study of 1-methylcytosine and 5'-dCMP that sheds further light on the excited states of cytosine derivatives
|Title:||A comparative picosecond transient infrared study of 1-methylcytosine and 5'-dCMP that sheds further light on the excited states of cytosine derivatives||Authors:||Keane, Páraic M.
Doorley, Gerard W.
Watson, Graeme W.
Clark, Ian P.
Greetham, Gregory M.
Parker, Anthony W.
Kelly, John M.
Quinn, Susan J.
|Permanent link:||http://hdl.handle.net/10197/4323||Date:||Mar-2011||Abstract:||The role of N1-substitution in controlling the deactivation processes in photoexcited cytosine derivatives has been explored using picosecond time-resolved IR spectroscopy. The simplest N1-substituted derivative, 1-methylcytosine, exhibits relaxation dynamics similar to the cytosine nucleobase and distinct from the biologically relevant nucleotide and nucleoside analogues, which have longer-lived excited-state intermediates. It is suggested that this is the case because the sugar group either facilitates access to the long-lived (1)n(O)Ï * state or retards its crossover to the ground state.||Type of material:||Journal Article||Publisher:||ACS Publications||Copyright (published version):||2011 American Chemical Society||Keywords:||Cytosine derivatives;1-methylcytosine;Infrared spectroscopy||DOI:||10.1021/ja1106089||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Chemistry Research Collection|
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