Synthesis and photophysical evaluations of fluorescent quaternary bipyridyl-1,8-naphthalimide conjugates as nucleic acid targeting agents
|Title:||Synthesis and photophysical evaluations of fluorescent quaternary bipyridyl-1,8-naphthalimide conjugates as nucleic acid targeting agents||Authors:||Ryan, Gary J.
Elmes, Robert B.P.
Quinn, Susan J.
|Permanent link:||http://hdl.handle.net/10197/4324||Date:||16-Jan-2012||Abstract:||A family of organic molecules containing the DNA intercalating chromophores, 4-nitro- and 4-amino 1,8-naphthalimide, conjugated to a diquat derivative by an ‘orthogonal’ phenyl spacer have been prepared and characterised. Their binding interactions with double-stranded DNA were studied by a variety of spectroscopic techniques. These charged organic compounds are found to exhibit excellent binding affinities to DNA with binding constants comparable to those exhibited by metal complexes.||Type of material:||Journal Article||Publisher:||Taylor & Francis||Copyright (published version):||2012, Taylor & Francis||Keywords:||DNA probes;Naphthalimide;Fluorescence;Sensors;Supramolecular systems||DOI:||10.1080/10610278.2011.638381||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Chemistry Research Collection|
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