Synthesis and photophysical evaluations of fluorescent quaternary bipyridyl-1,8-naphthalimide conjugates as nucleic acid targeting agents

Files in This Item:
File Description SizeFormat 
2012_Ryan_Supramol.pdf1.1 MBAdobe PDFDownload
Title: Synthesis and photophysical evaluations of fluorescent quaternary bipyridyl-1,8-naphthalimide conjugates as nucleic acid targeting agents
Authors: Ryan, Gary J.
Elmes, Robert B.P.
Quinn, Susan J.
Gunnlaugsson, Thorfinnur
Permanent link: http://hdl.handle.net/10197/4324
Date: 16-Jan-2012
Abstract:  A family of organic molecules containing the DNA intercalating chromophores, 4-nitro- and 4-amino 1,8-naphthalimide, conjugated to a diquat derivative by an ‘orthogonal’ phenyl spacer have been prepared and characterised. Their binding interactions with double-stranded DNA were studied by a variety of spectroscopic techniques. These charged organic compounds are found to exhibit excellent binding affinities to DNA with binding constants comparable to those exhibited by metal complexes.
Type of material: Journal Article
Publisher: Taylor & Francis
Copyright (published version): 2012, Taylor & Francis
Keywords: DNA probes;Naphthalimide;Fluorescence;Sensors;Supramolecular systems
DOI: 10.1080/10610278.2011.638381
Language: en
Status of Item: Peer reviewed
Appears in Collections:Chemistry Research Collection

Show full item record

SCOPUSTM   
Citations 20

14
Last Week
0
Last month
checked on Jun 23, 2018

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.