Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation.
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|Title:||Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation.||Authors:||Elmes, Robert B.P.
Cloonan, Suzanne M.
Quinn, Susan J.
Williams, D. Clive
|Permanent link:||http://hdl.handle.net/10197/4325||Date:||2011||Abstract:||The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.||Type of material:||Journal Article||Publisher:||RSC Publishing||Journal:||Chemical communications (Cambridge, England)||Volume:||47||Issue:||2||Start page:||686||End page:||688||Copyright (published version):||2011, Royal Society of Chemistry||Keywords:||Quaternarized polypyridyl ligands; Cell death; DNA binding; Cancer||DOI:||10.1039/c0cc04303f||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Chemistry Research Collection|
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