Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation.

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Title: Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation.
Authors: Elmes, Robert B.P.
Erby, Marialuisa
Cloonan, Suzanne M.
Quinn, Susan J.
Williams, D. Clive
Gunnlaugsson, Thorfinnur
Permanent link: http://hdl.handle.net/10197/4325
Date: 2011
Abstract: The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.
Type of material: Journal Article
Publisher: RSC Publishing
Journal: Chemical communications (Cambridge, England)
Volume: 47
Issue: 2
Start page: 686
End page: 688
Copyright (published version): 2011, Royal Society of Chemistry
Keywords: Quaternarized polypyridyl ligandsCell deathDNA bindingCancer
DOI: 10.1039/c0cc04303f
Language: en
Status of Item: Peer reviewed
Appears in Collections:Chemistry Research Collection

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