Electromechanical properties of dried tendon and iso-electrically focused collagen hydrogels

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Title: Electromechanical properties of dried tendon and iso-electrically focused collagen hydrogels
Authors: Denning, Denise
Abu-Rub, M. T.
Zeugolis, D. I.
Habelitz, S.
Pandit, A.
Fertala, A.
Rodriguez, Brian J.
Permanent link: http://hdl.handle.net/10197/4360
Date: Aug-2012
Online since: 2013-06-10T12:16:21Z
Abstract: Assembling artificial collagenous tissues with structural, functional, and mechanical properties which mimic natural tissues is of vital importance for many tissue engineering applications. While the electro-mechanical properties of collagen are thought to play a role in, for example, bone formation and remodeling, this functional property has not been adequately addressed in engineered tissues. Here the electro-mechanical properties of rat tail tendon are compared with those of dried isoelectrically focused collagen hydrogels using piezoresponse force microscopy under ambient conditions. In both the natural tissue and the engineered hydrogel D-periodic type I collagen fibrils are observed, which exhibit shear piezoelectricity. While both tissues also exhibit fibrils with parallel orientations, Fourier transform analysis has revealed that the degree of parallel alignment of the fibrils in the tendon is three times that of the dried hydrogel. The results obtained demonstrate that isoelectrically focused collagen has similar structural and electro-mechanical properties to that of tendon, which is relevant for tissue engineering applications.
Type of material: Journal Article
Publisher: Elsevier
Journal: Acta biomaterialia
Volume: 8
Issue: 8
Start page: 3073
End page: 3079
Copyright (published version): 2012 Acta Materialia Inc. Published by Elsevier Ltd.
Keywords: Atomic force microscopyPiezoelectricityCollagenIsoelectric focusingTissue engineering
DOI: 10.1016/j.actbio.2012.04.017
Other versions: http://dx.doi.org/10.1016/j.actbio.2012.04.017
Language: en
Status of Item: Peer reviewed
Appears in Collections:Physics Research Collection

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