A genome-wide scan for common alleles affecting risk for autism

Files in This Item:
File Description SizeFormat 
Anney_2010.pdf216.57 kBAdobe PDFDownload
Title: A genome-wide scan for common alleles affecting risk for autism
Authors: Anney, RichardKlei, LambertusPinto, DalilaRegan, ReginaCasey, JillianSegurado, RicardoShah, NaishaEnnis, Seanet al.
Permanent link: http://hdl.handle.net/10197/4375
Date: 27-Jul-2010
Online since: 2013-06-19T12:04:57Z
Abstract: Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ASD. In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P < 5 × 10−8. When a smaller replication sample was analyzed, the risk allele at rs4141463 was again over-transmitted; yet, consistent with the winner's curse, its effect size in the replication sample was much smaller; and, for the combined samples, the association signal barely fell below the P < 5 × 10−8 threshold. Exploratory analyses of phenotypic subtypes yielded no significant associations after correction for multiple testing. They did, however, yield strong signals within several genes, KIAA0564, PLD5, POU6F2, ST8SIA2 and TAF1C.
Type of material: Journal Article
Publisher: Oxford University Press
Journal: Human Molecular Genetics
Volume: 19
Issue: 20
Start page: 4072
End page: 4082
Copyright (published version): 2010, the author
Keywords: Autism spectrum disordersGenotypingSNP association
DOI: 10.1093/hmg/ddq307
Language: en
Status of Item: Peer reviewed
Appears in Collections:Public Health, Physiotherapy and Sports Science Research Collection

Show full item record

Citations 1

Last Week
Last month
checked on Aug 9, 2020

Page view(s) 5

Last Week
Last month
checked on Aug 9, 2020

Download(s) 20

checked on Aug 9, 2020

Google ScholarTM



This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.