The transsulfuration pathway : a source of cysteine for glutathione in astrocytes
Files in This Item:
|McBean_Transsulfuration_review_2012.pdf||167.19 kB||Adobe PDF||Download|
|Title:||The transsulfuration pathway : a source of cysteine for glutathione in astrocytes||Authors:||McBean, Gethin J.||Permanent link:||http://hdl.handle.net/10197/4493||Date:||Jan-2012||Abstract:||Astrocyte cells require cysteine as a substrate for glutamate cysteine ligase (γ-glutamylcysteine synthase; EC 188.8.131.52) catalyst of the rate-limiting step of the γ-glutamylcycle leading to formation of glutathione (l-γ-glutamyl-l-cysteinyl-glycine; GSH). In both astrocytes and glioblastoma/astrocytoma cells, the majority of cysteine originates from reduction of cystine imported by the x c − cystine-glutamate exchanger. However, the transsulfuration pathway, which supplies cysteine from the indispensable amino acid, methionine, has recently been identified as a significant contributor to GSH synthesis in astrocytes. The purpose of this review is to evaluate the importance of the transsulfuration pathway in these cells, particularly in the context of a reserve pathway that channels methionine towards cysteine when the demand for glutathione is high, or under conditions in which the supply of cystine by the x c − exchanger may be compromised.||Type of material:||Journal Article||Publisher:||Springer||Copyright (published version):||2012 Springer||Keywords:||Transulfuration;Brain;Astrocyte;Cysteine;Cystathionine-gamma-lyase;Cystathionine-beta-synthase;Glutathione||DOI:||10.1007/s00726-011-0864-8||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Biomolecular and Biomedical Science Research Collection|
Show full item record
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.