The transsulfuration pathway : a source of cysteine for glutathione in astrocytes
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|Title:||The transsulfuration pathway : a source of cysteine for glutathione in astrocytes||Authors:||McBean, Gethin J.||Permanent link:||http://hdl.handle.net/10197/4493||Date:||Jan-2012||Abstract:||Astrocyte cells require cysteine as a substrate for glutamate cysteine ligase (γ-glutamylcysteine synthase; EC 126.96.36.199) catalyst of the rate-limiting step of the γ-glutamylcycle leading to formation of glutathione (l-γ-glutamyl-l-cysteinyl-glycine; GSH). In both astrocytes and glioblastoma/astrocytoma cells, the majority of cysteine originates from reduction of cystine imported by the x c − cystine-glutamate exchanger. However, the transsulfuration pathway, which supplies cysteine from the indispensable amino acid, methionine, has recently been identified as a significant contributor to GSH synthesis in astrocytes. The purpose of this review is to evaluate the importance of the transsulfuration pathway in these cells, particularly in the context of a reserve pathway that channels methionine towards cysteine when the demand for glutathione is high, or under conditions in which the supply of cystine by the x c − exchanger may be compromised.||Type of material:||Journal Article||Publisher:||Springer||Journal:||Amino Acids||Volume:||42||Issue:||1||Start page:||199||End page:||205||Copyright (published version):||2012 Springer||Keywords:||Transulfuration; Brain; Astrocyte; Cysteine; Cystathionine-gamma-lyase; Cystathionine-beta-synthase; Glutathione||DOI:||10.1007/s00726-011-0864-8||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Biomolecular and Biomedical Science Research Collection|
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