The transsulfuration pathway : a source of cysteine for glutathione in astrocytes

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Title: The transsulfuration pathway : a source of cysteine for glutathione in astrocytes
Authors: McBean, Gethin J.
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Date: Jan-2012
Abstract: Astrocyte cells require cysteine as a substrate for glutamate cysteine ligase (γ-glutamylcysteine synthase; EC catalyst of the rate-limiting step of the γ-glutamylcycle leading to formation of glutathione (l-γ-glutamyl-l-cysteinyl-glycine; GSH). In both astrocytes and glioblastoma/astrocytoma cells, the majority of cysteine originates from reduction of cystine imported by the x c − cystine-glutamate exchanger. However, the transsulfuration pathway, which supplies cysteine from the indispensable amino acid, methionine, has recently been identified as a significant contributor to GSH synthesis in astrocytes. The purpose of this review is to evaluate the importance of the transsulfuration pathway in these cells, particularly in the context of a reserve pathway that channels methionine towards cysteine when the demand for glutathione is high, or under conditions in which the supply of cystine by the x c − exchanger may be compromised.
Type of material: Journal Article
Publisher: Springer
Journal: Amino Acids
Volume: 42
Issue: 1
Start page: 199
End page: 205
Copyright (published version): 2012 Springer
Keywords: TransulfurationBrainAstrocyteCysteineCystathionine-gamma-lyaseCystathionine-beta-synthaseGlutathione
DOI: 10.1007/s00726-011-0864-8
Language: en
Status of Item: Peer reviewed
Appears in Collections:Biomolecular and Biomedical Science Research Collection

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