Theoretical framework for nanoparticle uptake and accumulation kinetics in dividing cell populations

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Title: Theoretical framework for nanoparticle uptake and accumulation kinetics in dividing cell populations
Authors: Åberg, Christoffer
Kim, Jong Ah
Salvati, Anna
Dawson, Kenneth A.
Permanent link: http://hdl.handle.net/10197/4570
Date: Feb-2013
Online since: 2013-09-12T09:04:32Z
Abstract: Nano-sized objects interact with biological systems in fundamentally novel ways, thereby holding great promise for targeted drug delivery. It has also been suggested they could constitute a hitherto unseen hazard. Numerous experimental studies in the field are taking place. We consider that the nature of the interactions allows a more fundamental theoretical framework to be developed. In particular, we describe the intimate link that develops between nanoparticle uptake and cell population evolution. Explicit analytical results are given and the theory compared to experimental observations.
Type of material: Journal Article
Publisher: IOP Science
Journal: EPL : Europhysics Letters
Volume: 101
Issue: 3
Start page: 38007
Copyright (published version): EPLA, 2013
Keywords: Molecule-cell interactionsTargeted drug deliveryCell population evolutionNanoparticle-cell interactions
DOI: 10.1209/0295-5075/101/38007
Language: en
Status of Item: Peer reviewed
Appears in Collections:Chemistry Research Collection

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