Biomolecular coronas provide the biological identity of nanosized materials

Files in This Item:
File Description SizeFormat 
NNANO-12030435B-Dawson-AL_1350526345_2.pdf716.79 kBAdobe PDFDownload
Title: Biomolecular coronas provide the biological identity of nanosized materials
Authors: Monopoli, Marco P.
Åberg, Christoffer
Salvati, Anna
Dawson, Kenneth A.
Permanent link:
Date: 5-Dec-2012
Abstract: The search for understanding the interactions of nanosized materials with living organisms is leading to the rapid development of key applications, including improved drug delivery by targeting nanoparticles, and resolution of the potential threat of nanotechnological devices to organisms and the environment. Unless they are specifically designed to avoid it, nanoparticles in contact with biological fluids are rapidly covered by a selected group of biomolecules to form a corona that interacts with biological systems. Here we review the basic concept of the nanoparticle corona and its structure and composition, and highlight how the properties of the corona may be linked to its biological impacts. We conclude with a critical assessment of the key problems that need to be resolved in the near future.
Type of material: Journal Article
Publisher: Nature Publishing Group
Journal: Nature nanotechnology
Volume: 7
Issue: 12
Start page: 779
End page: 786
Copyright (published version): 2012 Macmillan Publishers Limited
Keywords: NanomaterialsNanomedicineNanoparticles
DOI: 10.1038/nnano.2012.207
Language: en
Status of Item: Peer reviewed
Appears in Collections:Chemistry Research Collection

Show full item record

Citations 1

Last Week
Last month
checked on Oct 19, 2018

Google ScholarTM



This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.