Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest
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|Title:||Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest||Authors:||Kim, Jong Ah
de Cárcer, Guillermo
Dawson, Kenneth A.
|Permanent link:||http://hdl.handle.net/10197/4574||Date:||13-Aug-2013||Online since:||2014-08-13T03:00:07Z||Abstract:||The interaction of nanoscaled materials with biological systems is currently the focus of a fast-growing area of investigation. Though many nanoparticles interact with cells without acute toxic responses, amino-modified polystyrene nanoparticles are known to induce cell death. We have found that by lowering their dose, cell death remains low for several days while, interestingly, cell cycle progression is arrested. In this scenario, nanoparticle uptake, which we have recently shown to be affected by cell cycle progression, develops differently over time due to the absence of cell division. This suggests that the same nanoparticles can trigger different pathways depending on exposure conditions and the dose accumulated.||Type of material:||Journal Article||Publisher:||ACS Publications||Journal:||ACS NANO||Volume:||7||Issue:||9||Start page:||7483||End page:||7494||Copyright (published version):||2013 American Chemical Society||Keywords:||Nanoparticle; Cell cycle arrest; Nanotoxicity; Cationic nanoparticles; Nanoparticle uptake; Lysosome; Cell division||DOI:||10.1021/nn403126e||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Chemistry Research Collection|
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