Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest

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Title: Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest
Authors: Kim, Jong Ah
Åberg, Christoffer
de Cárcer, Guillermo
Malumbres, Marcos
Salvati, Anna
Dawson, Kenneth A.
Permanent link: http://hdl.handle.net/10197/4574
Date: 13-Aug-2013
Online since: 2014-08-13T03:00:07Z
Abstract: The interaction of nanoscaled materials with biological systems is currently the focus of a fast-growing area of investigation. Though many nanoparticles interact with cells without acute toxic responses, amino-modified polystyrene nanoparticles are known to induce cell death. We have found that by lowering their dose, cell death remains low for several days while, interestingly, cell cycle progression is arrested. In this scenario, nanoparticle uptake, which we have recently shown to be affected by cell cycle progression, develops differently over time due to the absence of cell division. This suggests that the same nanoparticles can trigger different pathways depending on exposure conditions and the dose accumulated.
Type of material: Journal Article
Publisher: ACS Publications
Journal: ACS NANO
Volume: 7
Issue: 9
Start page: 7483
End page: 7494
Copyright (published version): 2013 American Chemical Society
Keywords: NanoparticleCell cycle arrestNanotoxicityCationic nanoparticlesNanoparticle uptakeLysosomeCell division
DOI: 10.1021/nn403126e
Language: en
Status of Item: Peer reviewed
Appears in Collections:Chemistry Research Collection

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