Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest

DC FieldValueLanguage
dc.contributor.authorKim, Jong Ah
dc.contributor.authorÅberg, Christoffer
dc.contributor.authorde Cárcer, Guillermo
dc.contributor.authorMalumbres, Marcos
dc.contributor.authorSalvati, Anna
dc.contributor.authorDawson, Kenneth A.
dc.date.accessioned2013-09-13T08:58:38Z
dc.date.available2014-08-13T03:00:07Z-
dc.date.copyright2013 American Chemical Societyen
dc.date.issued2013-08-13
dc.identifier.citationACS NANOen
dc.identifier.urihttp://hdl.handle.net/10197/4574
dc.description.abstractThe interaction of nanoscaled materials with biological systems is currently the focus of a fast-growing area of investigation. Though many nanoparticles interact with cells without acute toxic responses, amino-modified polystyrene nanoparticles are known to induce cell death. We have found that by lowering their dose, cell death remains low for several days while, interestingly, cell cycle progression is arrested. In this scenario, nanoparticle uptake, which we have recently shown to be affected by cell cycle progression, develops differently over time due to the absence of cell division. This suggests that the same nanoparticles can trigger different pathways depending on exposure conditions and the dose accumulated.en
dc.language.isoenen
dc.publisherACS Publicationsen
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Nano, copyright © 2013 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/nn403126e.en
dc.subjectNanoparticleen
dc.subjectCell cycle arresten
dc.subjectNanotoxicityen
dc.subjectCationic nanoparticlesen
dc.subjectNanoparticle uptakeen
dc.subjectLysosomeen
dc.subjectCell divisionen
dc.titleLow Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arresten
dc.typeJournal Articleen
dc.internal.authorcontactotherchristoffer.aberg@cbni.ucd.ie
dc.internal.availabilityFull text availableen
dc.statusPeer revieweden
dc.identifier.volume7en
dc.identifier.issue9
dc.identifier.startpage7483
dc.identifier.endpage7494
dc.identifier.doi10.1021/nn403126e-
dc.neeo.contributorKim|Jong Ah|aut|-
dc.neeo.contributorÅberg|Christoffer|aut|-
dc.neeo.contributorde Cárcer|Guillermo|aut|-
dc.neeo.contributorMalumbres|Marcos|aut|-
dc.neeo.contributorSalvati|Anna|aut|-
dc.neeo.contributorDawson|Kenneth A.|aut|-
dc.description.adminAMSen
dc.internal.rmsid355286156
dc.date.updated2013-08-21T13:00:56Z
item.grantfulltextopen-
item.fulltextWith Fulltext-
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