Experimental Device for Simulating Traumatic Brain Injury Resulting from Linear Accelerations

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Title: Experimental Device for Simulating Traumatic Brain Injury Resulting from Linear Accelerations
Authors: Gilchrist, M. D.
Permanent link: http://hdl.handle.net/10197/4677
Date: Nov-2004
Online since: 2013-10-02T09:15:49Z
Abstract: Various methods are used to model and analyse traumatic brain injuries (TBI) in the human. These include volunteer and cadaver experiments, anthropomorphic dummies, physical models, computational models and mathematical models. The pathophysiological response to mechanical impact of the human central nervous system and of in-vivo neural tissue is most realistically analysed using animal models, which provide the best surrogate for the human brain. During non-fatal impacts, a mechanical insult may trigger a cascade of physiological processes, many mediated by neurochemicals within the neural tissue which will, in turn, control the depth and extent of the brain injury. This present paper reports the development of a novel experimental device which can apply different linear acceleration impacts directly to in-vivo neural tissue in a manner which permits the experimental analysis of non-fatal TBI of varying severity.
Type of material: Journal Article
Publisher: Wiley Blackwell (Blackwell Publishing)
Journal: Strain
Volume: 40
Issue: 4
Start page: 180
End page: 192
Copyright (published version): 2004 Wiley Blackwell (Blackwell Publishing)
Keywords: Traumatic brain injury (TBI)Tissue damageLinear accelerationIimpact biomechanicsExperimental device
DOI: 10.1111/j.1475-1305.2004.00168.x
Language: en
Status of Item: Peer reviewed
Appears in Collections:Mechanical & Materials Engineering Research Collection

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