Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum
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|Title:||Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum||Authors:||Clark, Benjamin R.
Murphy, Cormac D.
|Permanent link:||http://hdl.handle.net/10197/4911||Date:||31-Oct-2008||Abstract:||The biosynthesis of the pyrrolylpolyene rumbrin (1) in the fungus Auxarthron umbrinum was elucidated using feeding studies with labelled precursors. Incorporation of stable isotopes from [15N]-proline, [13C]-methionine and [13C]-acetate confirmed that these were the precursors of the pyrrole moiety, methyl groups, and backbone of rumbrin, respectively. Label-dilution experiments with pyrrole-2-carboxylate confirmed it was a direct precursor in the biosynthesis of rumbrin. Both 3- and 4-chloropyrrolecarboxylates were also accepted as precursors in polyene production.||Type of material:||Journal Article||Publisher:||Royal Society of Chemistry||Copyright (published version):||2009, Royal Society of Chemistry||Keywords:||Polyene production||DOI:||10.1039/b813236d||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Biomolecular and Biomedical Science Research Collection|
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