Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum

DC FieldValueLanguage
dc.contributor.authorClark, Benjamin R.-
dc.contributor.authorMurphy, Cormac D.-
dc.date.accessioned2013-11-12T09:12:27Z-
dc.date.available2013-11-12T09:12:27Z-
dc.date.copyright2009, Royal Society of Chemistryen
dc.date.issued2008-10-31-
dc.identifier.citationOrganic and Biomolecular Chemistryen
dc.identifier.urihttp://hdl.handle.net/10197/4911-
dc.description.abstractThe biosynthesis of the pyrrolylpolyene rumbrin (1) in the fungus Auxarthron umbrinum was elucidated using feeding studies with labelled precursors. Incorporation of stable isotopes from [15N]-proline, [13C]-methionine and [13C]-acetate confirmed that these were the precursors of the pyrrole moiety, methyl groups, and backbone of rumbrin, respectively. Label-dilution experiments with pyrrole-2-carboxylate confirmed it was a direct precursor in the biosynthesis of rumbrin. Both 3- and 4-chloropyrrolecarboxylates were also accepted as precursors in polyene production.en
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.subjectPolyene productionen
dc.titleBiosynthesis of pyrrolylpolyenes in Auxarthron umbrinumen
dc.typeJournal Articleen
dc.internal.authorcontactothercormac.d.murphy@ucd.ie-
dc.internal.availabilityFull text availableen
dc.internal.webversionshttp://xlink.rsc.org/?doi=B813236D-
dc.statusPeer revieweden
dc.identifier.volume7en
dc.identifier.issue1en
dc.identifier.startpage111en
dc.identifier.endpage116en
dc.identifier.doi10.1039/b813236d-
dc.neeo.contributorClark|Benjamin R.|aut|-
dc.neeo.contributorMurphy|Cormac D.|aut|-
dc.description.adminAuthor has checked copyrighten
dc.description.adminAuthor contacted about proprietary files, awaiting response - OR 08/10/2013en
dc.description.admin11/11/2013. SB.en
dc.internal.rmsid74061718-
dc.date.updated2013-10-03T13:20:40Z-
item.fulltextWith Fulltext-
item.grantfulltextopen-
Appears in Collections:Biomolecular and Biomedical Science Research Collection
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