Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

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Title: Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface
Authors: Salvati, Anna
Pitek, Andrzej S.
Monopoli, Marco P.
Prapainop, Kanlaya
Baldelli Bombelli, Francesca
Hristov, Delyan R.
Kelly, Philip
Åberg, Christoffer
Mahon, Eugene
Dawson, Kenneth A.
Permanent link: http://hdl.handle.net/10197/4976
Date: 20-Jan-2013
Abstract: Nanoparticles have been proposed as carriers for drugs, genes and therapies to treat various diseases1, 2. Many strategies have been developed to target nanomaterials to specific or over-expressed receptors in diseased cells, and these typically involve functionalizing the surface of nanoparticles with proteins, antibodies or other biomolecules. Here, we show that the targeting ability of such functionalized nanoparticles may disappear when they are placed in a biological environment. Using transferrin-conjugated nanoparticles, we found that proteins in the media can shield transferrin from binding to both its targeted receptors on cells and soluble transferrin receptors. Although nanoparticles continue to enter cells, the targeting specificity of transferrin is lost. Our results suggest that when nanoparticles are placed in a complex biological environment, interaction with other proteins in the medium and the formation of a protein corona3, 4 can ‘screen’ the targeting molecules on the surface of nanoparticles and cause loss of specificity in targeting.
Type of material: Journal Article
Publisher: Nature Publishing Group
Keywords: NanomedicineEnvironmentalHealth and safety issues
DOI: 10.1038/nnano.2012.237
Language: en
Status of Item: Peer reviewed
Appears in Collections:Chemistry Research Collection

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