Advances in mesenchymal stem cell-mediated gene therapy for cancer

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Title: Advances in mesenchymal stem cell-mediated gene therapy for cancer
Authors: Dwyer, Roisin M.
Khan, Sonja
Barry, Frank P.
et al.
Permanent link: http://hdl.handle.net/10197/5001
Date: 2010
Abstract: Mesenchymal stem cells have a natural tropism for tumours and their metastases, and are also considered immunoprivileged. This remarkable combination of properties has formed the basis for many studies investigating their potential as tumour-specific delivery vehicles for suicide genes, oncolytic viruses and secreted therapeutic proteins. The aim of the present review is to discuss the range of approaches that have been used to exploit the tumour-homing capacity of mesenchymal stem cells for gene delivery, and to highlight advances required to realize the full potential of this promising approach.
Type of material: Journal Article
Publisher: Springer (Biomed Central Ltd.)
Copyright (published version): 2010 Springer (Biomed Central Ltd.)
Keywords: mesenchymal stem cells (MSCs);targeted gene delivery;gene therapy;cancer
DOI: 10.1186/scrt25
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
SBI Research Collection

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