Physiological Temperature Has a Crucial Role in Amyloid Beta in the Absence and Presence of Hydrophobic and Hydrophilic Nanoparticles

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Title: Physiological Temperature Has a Crucial Role in Amyloid Beta in the Absence and Presence of Hydrophobic and Hydrophilic Nanoparticles
Authors: Ghavami, Mahdi
Rezaei, Meisam
Ejtehadi, Reza
et al.
Permanent link: http://hdl.handle.net/10197/5003
Date: 20-Mar-2013
Online since: 2014-03-20T04:00:13Z
Abstract: Amyloid beta fibrillation can lead to major disorder of neurons processes and is associated with several neuronal diseases (e.g., Alzheimer’s disease). We report here an importance of slight temperature changes, in the physiological range (35–42 °C), on the amyloid fibrillation process in the presence and absence of hydrophilic (silica) and hydrophobic (polystyrene) nanoparticles (NPs). The results highlight the fact that slight increases in temperature can induce inhibitory and acceleratory effects of hydrophobic and hydrophilic NPs on the fibrillation process, respectively. Using further in vivo considerations, the outcomes of this study can be used for considerable modifications on the current diagnosis and treatment approaches in amyloid-involved diseases.
Type of material: Journal Article
Publisher: American Chemical Society
Journal: ACS Chemical Neuroscience
Volume: 4
Issue: 3
Start page: 375
End page: 378
Copyright (published version): 2013 American Chemical Society
Keywords: Amyloid betafibrillationphysiological temperaturehydrophilic NPshydrophobic NPs
DOI: 10.1021/cn300205g
Language: en
Status of Item: Peer reviewed
Appears in Collections:SBI Research Collection

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