Genetically modified mesenchymal stem cells and their clinical potential in acute cardiovascular disease.

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Title: Genetically modified mesenchymal stem cells and their clinical potential in acute cardiovascular disease.
Authors: Griffin, Matthew
Greiser, Udo
Barry, Frank P.
et al.
Permanent link: http://hdl.handle.net/10197/5004
Date: 14-Mar-2010
Abstract: Adult mesenchymal stem cells (MSCs) are non-hematopoietic cells with multi-lineage potential to differentiate into various tissues of mesodermal origin. They can be isolated from bone marrow and other tissues and have the capacity to extensively proliferate in vitro. Moreover, MSCs have also been shown to produce anti-inflammatory molecules which can modulate humoral and cellular immune responses. Considering their regenerative potential and immunoregulatory effect, MSC therapy is a promising tool in the treatment of degenerative, inflammatory, and autoimmune diseases. However, the current understanding from results of clinical trials is that MSC-therapy is safe but its therapeutic efficiency needs to be improved. In this article we will focus on options for genetic manipulation of MSCs and on current progress in adapting genetically-modified MSCs for clinical use in acute cardiovascular disease.
Type of material: Journal Article
Publisher: Discovery Medicine
Journal: Discovery Medicine
Volume: 9
Issue: 46
Start page: 219
End page: 223
Copyright (published version): 2010 Discovery Medicine
Keywords: Medical SpecialtiesLife SciencesSpecies and Cell TypesResearch TechnologyTherapeutic Technology and MethodologyPharmaceutical and Healthcare Indusrty
Language: en
Status of Item: Peer reviewed
Appears in Collections:SBI Research Collection

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