The role of progesterone in implantation and trophoblast invasion

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Title: The role of progesterone in implantation and trophoblast invasion
Authors: Halasz, Melinda
Szekeres-Bartho, Julia
Permanent link: http://hdl.handle.net/10197/5006
Date: Mar-2013
Abstract: With its genomic and non-genomic actions, progesterone plays a role in preparing the endometrium for implantation and also in regulating trophoblast invasion and migration. The genomic actions of progesterone are mediated by the classical nuclear progesterone receptors, PR-A and PR-B. In addition to their genomic actions, nuclear progesterone receptors may also trigger rapid cytoplasmic signalling events. Membrane-bound progesterone receptors have been implicated in the rapid non-genomic actions of progesterone. Both genomic and extra-nuclear actions of progesterone are crucial for adequate decidualisation and implantation. Progesterone plays a role in establishing uterine receptivity by blocking the proliferative effect of oestrogen, by inducing genes that allow the endometrium to permit embryo attachment, and also acts as a negative regulator of trophoblast invasion by controlling matrix metalloproteinase (MMP) activity.
Type of material: Journal Article
Publisher: Elsevier
Copyright (published version): 2013 Elsevier
Keywords: Progesterone;Trophoblast;Invasion;Signalling
DOI: 10.1016/j.jri.2012.10.011
Language: en
Status of Item: Peer reviewed
Appears in Collections:SBI Research Collection

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