The role of progesterone in implantation and trophoblast invasion
|Title:||The role of progesterone in implantation and trophoblast invasion||Authors:||Halasz, Melinda
|Permanent link:||http://hdl.handle.net/10197/5006||Date:||Mar-2013||Online since:||2013-11-28T15:08:49Z||Abstract:||With its genomic and non-genomic actions, progesterone plays a role in preparing the endometrium for implantation and also in regulating trophoblast invasion and migration. The genomic actions of progesterone are mediated by the classical nuclear progesterone receptors, PR-A and PR-B. In addition to their genomic actions, nuclear progesterone receptors may also trigger rapid cytoplasmic signalling events. Membrane-bound progesterone receptors have been implicated in the rapid non-genomic actions of progesterone. Both genomic and extra-nuclear actions of progesterone are crucial for adequate decidualisation and implantation. Progesterone plays a role in establishing uterine receptivity by blocking the proliferative effect of oestrogen, by inducing genes that allow the endometrium to permit embryo attachment, and also acts as a negative regulator of trophoblast invasion by controlling matrix metalloproteinase (MMP) activity.||Type of material:||Journal Article||Publisher:||Elsevier||Journal:||Journal of Reproductive Immunology||Volume:||97||Issue:||1||Start page:||43||End page:||50||Copyright (published version):||2013 Elsevier||Keywords:||Progesterone; Trophoblast; Invasion; Signalling||DOI:||10.1016/j.jri.2012.10.011||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||SBI Research Collection|
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