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The role of progesterone in implantation and trophoblast invasion
Author(s)
Date Issued
2013-03
Date Available
2013-11-28T15:08:49Z
Abstract
With its genomic and non-genomic actions, progesterone plays a role in preparing the endometrium for implantation and also in regulating trophoblast invasion and migration. The genomic actions of progesterone are mediated by the classical nuclear progesterone receptors, PR-A and PR-B. In addition to their genomic actions, nuclear progesterone receptors may also trigger rapid cytoplasmic signalling events. Membrane-bound progesterone receptors have been implicated in the rapid non-genomic actions of progesterone. Both genomic and extra-nuclear actions of progesterone are crucial for adequate decidualisation and implantation. Progesterone plays a role in establishing uterine receptivity by blocking the proliferative effect of oestrogen, by inducing genes that allow the endometrium to permit embryo attachment, and also acts as a negative regulator of trophoblast invasion by controlling matrix metalloproteinase (MMP) activity.
Other Sponsorship
Hungarian National Research Fund (OTKA 77717), from theUniversity of Pecs (34039/KA-PostDoc12-03) and by TÁMOP-4.2.1/B-10/1-2010-0002.
Type of Material
Journal Article
Publisher
Elsevier
Journal
Journal of Reproductive Immunology
Volume
97
Issue
1
Start Page
43
End Page
50
Copyright (Published Version)
2013 Elsevier
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
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