Liposomal gene delivery mediated by tissue-engineered scaffolds
|Title:||Liposomal gene delivery mediated by tissue-engineered scaffolds||Authors:||Kulkarni, Mangesh
|Permanent link:||http://hdl.handle.net/10197/5009||Date:||Jan-2010||Abstract:||In the absence of any ideal gene delivery carrier despite the recent explosion of novel carrier systems, the current trend is to explore the complementary synergy promised by a combination of delivery systems such as liposomes, which are the most widely researched versatile non-viral carriers, and tissue-engineered scaffolds with macrostructures of defined architecture comprised of natural or synthetic macromolecules. Here, we discuss the recent advances in liposomal gene delivery and the possible benefits of a combined liposome–scaffold approach, such as long-term expression, enhanced stability, reduction in toxicity and ability to produce spatio-temporal expression patterns. This approach is generating significant impact in the field as a result of its potential for extended localised gene delivery for applications in a variety of clinical conditions.||Type of material:||Journal Article||Publisher:||Elsevier||Journal:||Trends in Biotechnology||Volume:||28||Issue:||1||Start page:||28||End page:||36||Copyright (published version):||2010 Elsevier||Keywords:||liposomal gene delivery; combined liposome–scaffold approach||DOI:||10.1016/j.tibtech.2009.10.003||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||SBI Research Collection|
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