Liposomal gene delivery mediated by tissue-engineered scaffolds

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Title: Liposomal gene delivery mediated by tissue-engineered scaffolds
Authors: Kulkarni, Mangesh
Greiser, Udo
O'Brien, Timothy
et al.
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Date: Jan-2010
Abstract: In the absence of any ideal gene delivery carrier despite the recent explosion of novel carrier systems, the current trend is to explore the complementary synergy promised by a combination of delivery systems such as liposomes, which are the most widely researched versatile non-viral carriers, and tissue-engineered scaffolds with macrostructures of defined architecture comprised of natural or synthetic macromolecules. Here, we discuss the recent advances in liposomal gene delivery and the possible benefits of a combined liposome–scaffold approach, such as long-term expression, enhanced stability, reduction in toxicity and ability to produce spatio-temporal expression patterns. This approach is generating significant impact in the field as a result of its potential for extended localised gene delivery for applications in a variety of clinical conditions.
Type of material: Journal Article
Publisher: Elsevier
Journal: Trends in Biotechnology
Volume: 28
Issue: 1
Start page: 28
End page: 36
Copyright (published version): 2010 Elsevier
Keywords: liposomal gene deliverycombined liposome–scaffold approach
DOI: 10.1016/j.tibtech.2009.10.003
Language: en
Status of Item: Peer reviewed
Appears in Collections:SBI Research Collection

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