Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance

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Title: Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance
Authors: Aksamitiene, Edita
Kiyatkin, Anatoly B.
Kholodenko, Boris N.
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Date: 19-Jan-2012
Online since: 2013-11-28T17:34:35Z
Abstract: In the present paper, we describe multiple levels of cross-talk between the PI3K (phosphoinositide 3-kinase)/Akt and Ras/MAPK (mitogen-activated protein kinase) signalling pathways. Experimental data and computer simulations demonstrate that cross-talk is context-dependent and that both pathways can activate or inhibit each other. Positive influence of the PI3K pathway on the MAPK pathway is most effective at sufficiently low doses of growth factors, whereas negative influence of the MAPK pathway on the PI3K pathway is mostly pronounced at high doses of growth factors. Pathway cross-talk endows a cell with emerging capabilities for processing and decoding signals from multiple receptors activated by different combinations of extracellular cues.
Type of material: Journal Article
Publisher: Portland Press
Journal: Biochemical Society Transactions
Volume: 40
Issue: 1
Start page: 139
End page: 146
Copyright (published version): 2012 Portland Press
Keywords: Aktcross-talkmitogen-activated protein kinase (MAPK)phosphoinositide 3-kinase (PI3K)Ras
DOI: 10.1042/BST20110609
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
SBI Research Collection

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