Endocytosis and signalling: A meeting with mathematics

DC FieldValueLanguage
dc.contributor.authorBirtwistle, Marc R.en
dc.contributor.authorKholodenko, Boris N.en
dc.date.accessioned2013-11-29T09:23:46Z
dc.date.available2013-11-29T09:23:46Z
dc.date.copyright2009 Elsevieren
dc.date.issued2009-08en
dc.identifier.citationMolecular Oncologyen
dc.identifier.urihttp://hdl.handle.net/10197/5032
dc.description.abstractAlthough endocytosis has traditionally been understood as a signal attenuation mechanism, an emerging view considers endocytosis as an integral part of signal propagation and processing. On the short time scale, trafficking of endocytic vesicles contributes to signal propagation from the surface to distant targets, with bi-directional communication between signalling and trafficking. Mathematical modelling helps combine the mechanistic, molecular knowledge with rigorous analysis of the complex output dynamics of endocytosis in time and space. Simulations reveal novel roles for endocytosis, including the control of cell polarity, enhancing the spatial signal propagation, and controlling the signal magnitudes, kinetics, and synchronization with stimulus dynamics.en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsThis is the author's version of a work that was accepted for publication in Molecular Oncology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Molecular Oncology (3, 4, (2009)) DOI: http://dx.doi/org/10.1016/j.molonc.2009.05.009en
dc.subjectEndocytosisen
dc.subjectMathematical modellingen
dc.subjectSpatial gradientsen
dc.subjectSpatiotemporal dynamicsen
dc.subjectSignal transductionen
dc.titleEndocytosis and signalling: A meeting with mathematicsen
dc.typeJournal Articleen
dc.internal.availabilityFull text availableen
dc.statusPeer revieweden
dc.identifier.volume3en
dc.identifier.issue4en
dc.identifier.startpage308en
dc.identifier.endpage320en
dc.identifier.doi10.1016/j.molonc.2009.05.009-
dc.neeo.contributorBirtwistle|Marc R.|aut|-
dc.neeo.contributorKholodenko|Boris N.|aut|-
dc.internal.notesPaper102.pdfen
dc.description.othersponsorshipSFI & NIH grants GM059570 & R33HL088283en
dc.description.adminDeposited by bulk importen
dc.internal.rmsid181482133en
dc.date.updated2013-11-27T16:35:50.274Zen
item.fulltextWith Fulltext-
item.grantfulltextopen-
Appears in Collections:SBI Research Collection
Files in This Item:
File Description SizeFormat 
Paper102.pdf1.17 MBAdobe PDFDownload
Show simple item record

SCOPUSTM   
Citations 20

22
Last Week
0
Last month
checked on Sep 17, 2018

Page view(s) 50

33
checked on May 25, 2018

Download(s) 50

61
checked on May 25, 2018

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.