Positional Information Generated by Spatially Distributed Signaling Cascades

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Title: Positional Information Generated by Spatially Distributed Signaling Cascades
Authors: Muñoz-García, Javier
Neufeld, Zoltán
Kholodenko, Boris N.
et al.
Permanent link: http://hdl.handle.net/10197/5040
Date: 20-Mar-2009
Online since: 2013-11-29T09:38:59Z
Abstract: The temporal and stationary behavior of protein modification cascades has been extensively studied, yet little is known about the spatial aspects of signal propagation. We have previously shown that the spatial separation of opposing enzymes, such as a kinase and a phosphatase, creates signaling activity gradients. Here we show under what conditions signals stall in the space or robustly propagate through spatially distributed signaling cascades. Robust signal propagation results in activity gradients with long plateaus, which abruptly decay at successive spatial locations. We derive an approximate analytical solution that relates the maximal amplitude and propagation length of each activation profile with the cascade level, protein diffusivity, and the ratio of the opposing enzyme activities. The control of the spatial signal propagation appears to be very different from the control of transient temporal responses for spatially homogenous cascades. For spatially distributed cascades where activating and deactivating enzymes operate far from saturation, the ratio of the opposing enzyme activities is shown to be a key parameter controlling signal propagation. The signaling gradients characteristic for robust signal propagation exemplify a pattern formation mechanism that generates precise spatial guidance for multiple cellular processes and conveys information about the cell size to the nucleus.
Type of material: Journal Article
Publisher: Public Library of Science
Journal: PLoS Computational Biology
Volume: 5
Issue: 3
Start page: e1000330
Copyright (published version): 2009 Public Library of Science
Keywords: protein modification cascadessignal propagationspatial aspects
DOI: 10.1371/journal.pcbi.1000330
Language: en
Status of Item: Peer reviewed
Appears in Collections:SBI Research Collection

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