Spatially distributed cell signalling

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Title: Spatially distributed cell signalling
Authors: Kholodenko, Boris N.
Permanent link: http://hdl.handle.net/10197/5042
Date: Dec-2009
Abstract: Emerging evidence indicates that complex spatial gradients and (micro)domains of signalling activities arise from distinct cellular localization of opposing enzymes, such as a kinase and phosphatase, in signal transduction cascades. Often, an interacting, active form of a target protein has the lower diffusivity than an inactive form, and this leads to spatial gradients of the protein abundance in the cytoplasm. A spatially distributed signalling cascade can create step-like activation profiles, which decay at successive distances from the cell surface, assigning digital positional information to different regions in the cell. Feedback and feedforward network motifs control activity patterns, allowing signalling networks to serve as cellular devices for spatial computations.
Type of material: Journal Article
Publisher: Elsevier
Journal: FEBS Letters
Volume: 583
Issue: 24
Start page: 4006
End page: 4012
Copyright (published version): 2009 Elsevier
Keywords: signal transductionspatial gradientsprotein modification cyclespatiotemporal dynamics
DOI: 10.1016/j.febslet.2009.09.045
Language: en
Status of Item: Peer reviewed
Appears in Collections:SBI Research Collection

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