Biology using engineering tools: The negative feedback amplifier

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Title: Biology using engineering tools: The negative feedback amplifier
Authors: Birtwistle, Marc R.
Kolch, Walter
Permanent link: http://hdl.handle.net/10197/5061
Date: 1-Jul-2011
Online since: 2013-11-29T10:00:41Z
Abstract: Negative feedback is an ubiquitous feature of biological networks. Recent work from Sturm and colleaguespresents experimental evidence that biological negative feedback can serve the same function as it does for engineered systems: robustness to perturbations within the feedback loop. Such behavior has important implications for how to attack deregulated signaling networks containing negative feedback in diseases such as cancer.
Type of material: Journal Article
Publisher: Landes Bioscience
Journal: Cell Cycle
Volume: 10
Issue: 13
Start page: 2069
End page: 2076
Copyright (published version): 2011 Landes Bioscience
Keywords: negative feedbacksignal transductionquantitative modelingmitogen activated protein kinasespatiotemporal dynamics
DOI: 10.4161/cc.10.13.16245
Language: en
Status of Item: Peer reviewed
Appears in Collections:SBI Research Collection

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