Catching transcriptional regulation by thermostatistical modeling

Files in This Item:
File Description SizeFormat 
Paper78.pdf639.58 kBAdobe PDFDownload
Title: Catching transcriptional regulation by thermostatistical modeling
Authors: Frank, Till D.
Cheong, Alex
Okada-Hatakeyama, Mariko
et al.
Permanent link:
Date: 7-Aug-2012
Abstract: Gene expression is frequently regulated by multiple transcription factors (TFs). Thermostatistical methods allow for a quantitative description of interactions between TFs, RNA polymerase and DNA, and their impact on the transcription rates. We illustrate three different scales of the thermostatistical approach: the microscale of TF molecules, the mesoscale of promoter energy levels and the macroscale of transcriptionally active and inactive cells in a cell population. We demonstrate versatility of combinatorial transcriptional activation by exemplifying logic functions, such as AND and OR gates. We discuss a metric for cell-to-cell transcriptional activation variability known as Fermi entropy. Suitability of thermostatistical modeling is illustrated by describing the experimental data on transcriptional induction of NFκB and the c-Fos protein.
Type of material: Journal Article
Publisher: IOP Publishing
Copyright (published version): 2012 IOP Publishing
Keywords: General theory and mathematical aspectsNucleic acidsSpatiotemporal pattern formation in cellular populationsProteinsBiological physics
DOI: 10.1088/1478-3975/9/4/045007
Language: en
Status of Item: Peer reviewed
Appears in Collections:SBI Research Collection

Show full item record

Citations 50

Last Week
Last month
checked on Aug 17, 2018

Page view(s) 50

checked on May 25, 2018

Download(s) 50

checked on May 25, 2018

Google ScholarTM



This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.