Decisions, dopamine and degeneracy in complex biological systems

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Title: Decisions, dopamine and degeneracy in complex biological systems
Authors: Regan, Ciaran M.
Permanent link: http://hdl.handle.net/10197/5264
Date: Jan-2014
Abstract: The neurobiological and computational analysis of value-based decision-making rests within the domain of neuroeconomics which has the goal of providing a biological account of human behavior relevant to both natural and social sciences. This review proposes a framework to investigate different aspects of the theoretical and molecular neurobiology of decision-making. In order to learn how to make good decisions the brain needs to compute a separate value signal that measures the desirability of the outcomes that were generated by its previous decisions. The framework presented here combines aspects of current ideas relating to information processing by the hippocampal formation and how these relate to the phasic midbrain dopaminergic firing that occurs in response to the spatial and motivational aspects of rewarding events in the environment. The activities of hippocampal ensembles are considered to reflect a continuous updating process for attended experiences, defining both regular and irregular stimuli, environments and actions, which are rapidly encoded as schemas into pre-existing knowledge bases.
Type of material: Journal Article
Publisher: Dovepress
Copyright (published version): 2014 the Author
Keywords: Hippocampus;Schemas;Synapse assemblies;Cell assemblies;Synapse plasticity
DOI: 10.2147/NAN.S32234
Language: en
Status of Item: Peer reviewed
Appears in Collections:Biomolecular and Biomedical Science Research Collection

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