Genome-level analyses of Mycobacterium bovis lineages reveal the role of SNPs and antisense transcription in differential gene expression

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Title: Genome-level analyses of Mycobacterium bovis lineages reveal the role of SNPs and antisense transcription in differential gene expression
Authors: Golby, Paul
Nunez, Javier
Witney, Adam
Gordon, Stephen V.
et al.
Permanent link: http://hdl.handle.net/10197/5310
Date: Oct-2013
Abstract: Bovine tuberculosis (bTB) is a disease with major implications for animal welfare and productivity, as well as having the potential for zoonotic transmission. In Great Britain (GB) alone, controlling bTB costs in the region of £100 million annually, with the current control scheme seemingly unable to stop the inexorable spread of infection. One aspect that may be driving the epidemic is evolution of the causative pathogen, Mycobacterium bovis. To understand the underlying genetic changes that may be responsible for this evolution, we performed a comprehensive genome-level analyses of 4 M. bovis strains that encompass the main molecular types of the pathogen circulating in GB.
Type of material: Journal Article
Publisher: BioMed Central
Keywords: Bovine tuberculosis;Mycobacterium bovis;Microarray;Transcript;SNP;Antisense;Macrophage
DOI: 10.1186/1471-2164-14-710
Language: en
Status of Item: Peer reviewed
Appears in Collections:Veterinary Medicine Research Collection

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