Genome-level analyses of Mycobacterium bovis lineages reveal the role of SNPs and antisense transcription in differential gene expression

DC FieldValueLanguage
dc.contributor.authorGolby, Paul-
dc.contributor.authorNunez, Javier-
dc.contributor.authorWitney, Adam-
dc.contributor.authorGordon, Stephen V.-
dc.contributor.authoret al.-
dc.date.accessioned2014-01-29T10:04:20Z-
dc.date.available2014-01-29T10:04:20Z-
dc.date.issued2013-10-
dc.identifier.citationBMC Genomicsen
dc.identifier.urihttp://hdl.handle.net/10197/5310-
dc.description.abstractBovine tuberculosis (bTB) is a disease with major implications for animal welfare and productivity, as well as having the potential for zoonotic transmission. In Great Britain (GB) alone, controlling bTB costs in the region of £100 million annually, with the current control scheme seemingly unable to stop the inexorable spread of infection. One aspect that may be driving the epidemic is evolution of the causative pathogen, Mycobacterium bovis. To understand the underlying genetic changes that may be responsible for this evolution, we performed a comprehensive genome-level analyses of 4 M. bovis strains that encompass the main molecular types of the pathogen circulating in GB.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.subjectBovine tuberculosisen
dc.subjectMycobacterium bovisen
dc.subjectMicroarrayen
dc.subjectTranscripten
dc.subjectSNPen
dc.subjectAntisenseen
dc.subjectMacrophageen
dc.titleGenome-level analyses of Mycobacterium bovis lineages reveal the role of SNPs and antisense transcription in differential gene expressionen
dc.typeJournal Articleen
dc.internal.authorcontactotherstephen.gordon@ucd.ie-
dc.internal.availabilityFull text availableen
dc.statusPeer revieweden
dc.identifier.volume14en
dc.identifier.issue1en
dc.identifier.startpage710en
dc.identifier.doi10.1186/1471-2164-14-710-
dc.neeo.contributorGolby|Paul|aut|-
dc.neeo.contributorNunez|Javier|aut|-
dc.neeo.contributorWitney|Adam|aut|-
dc.neeo.contributorGordon|Stephen V.|aut|-
dc.neeo.contributoret al.||aut|-
dc.description.adminAuthor has checked copyrighten
dc.description.adminAMSen
dc.description.adminNo Pages Numbers.en
dc.internal.rmsid368142004-
dc.date.updated2014-01-17T12:09:21Z-
item.grantfulltextopen-
item.fulltextWith Fulltext-
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