Genetic pre-determinants of concurrent alcohol and opioid dependence: a critical review

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Title: Genetic pre-determinants of concurrent alcohol and opioid dependence: a critical review
Authors: Martin, Marissa
Klimas, Jan
Dunne, Colum
Meagher, David
O'Connor, William T.
O'Dwyer, Patrick
Smyth, Bobby P.
Cullen, Walter
Permanent link: http://hdl.handle.net/10197/5486
Date: Nov-2013
Abstract: Concurrent alcohol dependence poses a significant burden to health and wellbeing of people with established opioid dependence. Although previous research indicates that both genetic and environmental risk factors contribute to the development of drug or alcohol dependence, the role of genetic determinants in development of concurrent alcohol and opioid dependence has not been scrutinised. To search for genetic pre-determinants of concurrent alcohol and opioid dependence, electronic literature searches were completed using MEDLINE (PubMed) and EBSCO (Academic Search Complete) databases. Reference lists of included studies were also searched. In this discussion paper, we provide an overview of the genes (n=33) which are associated with the opioid, serotonergic, dopaminergic, GABA-ergic, cannabinoid, and metabolic systems for each dependency (i.e., alcohol or opioid) separately. The current evidence base is inconclusive regarding an exclusively genetic pre-determinant of concurrent alcohol and opioid dependence. Further search strategies and original research are needed to determine the genetic basis for concurrent alcohol and opioid dependency.
Type of material: Journal Article
Publisher: OA Publishing London
Copyright (published version): 2013 OA Publishing London
Keywords: Alcohol;Opioids;Substance-related disorders;Comorbidity;Genetic predisposition
Language: en
Status of Item: Not peer reviewed
Appears in Collections:Medicine Research Collection

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