Carbon dioxide-sensing in organisms and its implications for human disease

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Title: Carbon dioxide-sensing in organisms and its implications for human disease
Authors: Cummins, Eoin P.
Selfridge, Andrew C.
Sporn, Peter H.
et al.
Permanent link: http://hdl.handle.net/10197/5570
Date: 18-Sep-2013
Abstract: The capacity of organisms to sense changes in the levels of internal and external gases and to respond accordingly is central to a range of physiologic and pathophysiologic processes. Carbon dioxide, a primary product of oxidative metabolism is one such gas that can be sensed by both prokaryotic and eukaryotic cells and in response to altered levels, elicit the activation of multiple adaptive pathways. The outcomes of activating CO2-sensitive pathways in various species include increased virulence of fungal and bacterial pathogens, prey-seeking behavior in insects as well as taste perception, lung function, and the control of immunity in mammals. In this review, we discuss what is known about the mechanisms underpinning CO2 sensing across a range of species and consider the implications of this for physiology, disease progression, and the possibility of developing new therapeutics for inflammatory and infectious disease.
Type of material: Journal Article
Publisher: Springer-Verlag
Copyright (published version): 2013 Springer-Verlag
Keywords: Carbon dioxide (CO2);Hypercapnia;Physiological gases;Immune regulation;NF-kappaB
DOI: 10.1007/s00018-013-1470-6
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
SBI Research Collection

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