Signalling by protein phosphatases and drug development: a systems-centred view

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Title: Signalling by protein phosphatases and drug development: a systems-centred view
Authors: Nguyen, Lan K.
Matallanas, David
Croucher, David R.
et al.
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Date: 14-Mar-2012
Abstract: Protein modification cycles catalysed by opposing enzymes, such as kinases and phosphatases, form the backbone of signalling networks. Although, historically, kinases have been at the research forefront, a systems-centred approach reveals predominant roles for phosphatases in controlling the network response times and spatio-temporal profiles of signalling activities. Emerging evidence suggests that phosphatase kinetics are critical for network function and cell-fate decisions. Protein phosphatases operate as both immediate and delayed regulators of signal transduction, capable of attenuating or amplifying signalling. This versatility of phosphatase action emphasizes the need for systems biology approaches to understand cellular signalling networks and predict the cellular outcomes of combinatorial drug interventions.
Type of material: Journal Article
Publisher: Wiley Blackwell (Blackwell Publishing)
Journal: FEBS Journal
Volume: 280
Issue: 2
Start page: 751
End page: 765
Copyright (published version): 2012 Wiley Blackwell (Blackwell Publishing)
Keywords: computational modellingdrug discoverydrug interventionMAP kinasephosphatasesphosphatase-targeted therapiessignalling cascadesSHP2spatiotemporal dynamicssystems biology
DOI: 10.1111/j.1742-4658.2012.08522.x
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
SBI Research Collection

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