Signalling ballet in space and time

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Title: Signalling ballet in space and time
Authors: Kholodenko, Boris N.
Hancock, John F.
Kolch, Walter
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Date: Jun-2010
Abstract: Although we have amassed extensive catalogues of signalling network components, our understanding of the spatiotemporal control of emergent network structures has lagged behind. Dynamic behaviour is starting to be explored throughout the genome, but analysis of spatial behaviours is still confined to individual proteins. The challenge is to reveal how cells integrate temporal and spatial information to determine specific biological functions. Key findings are the discovery of molecular signalling machines such as Ras nanoclusters, spatial activity gradients and flexible network circuitries that involve transcriptional feedback. They reveal design principles of spatiotemporal organization that are crucial for network function and cell fate decisions.
Type of material: Journal Article
Publisher: Nature Publishing Group
Copyright (published version): 2010 Nature Publishing Group
Keywords: signalling network componentsspatiotemporal controltemporal signalling dynamicsRas nanoclusterscell fate decisions
DOI: 10.1038/nrm2901
Language: en
Status of Item: Peer reviewed
Appears in Collections:Conway Institute Research Collection
SBI Research Collection

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