Phosphodiesterases link the aryl hydrocarbon receptor complex to cyclic nucleotide signaling

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Title: Phosphodiesterases link the aryl hydrocarbon receptor complex to cyclic nucleotide signaling
Authors: Oliveira, Simone Kobe de
Smolenski, Albert P.
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Date: 15-Feb-2009
Online since: 2014-10-06T11:39:26Z
Abstract: The aryl hydrocarbon receptor (AHR) is a major transcription factor regulated by different mechanisms. The classical view of AHR activation by xenobiotics needs to be amended by recent findings on the regulation of AHR by endogenous ligands and by crosstalk with other signaling pathways. In the cytosol the AHR recruits a large number of binding partners, including HSP90, p23, XAP2 and the ubiquitin ligases cullin 4B and CHIP. Furthermore, XAP2 binds the cyclic nucleotide phosphodiesterases PDE2A and PDE4A5. PDE2A inhibits nuclear translocation of AHR suggesting an important regulatory role of cyclic nucleotides in AHR trafficking. Signaling involving cAMP is organized in subcellular compartments and a distinct cAMP compartment might be required for proper AHR mobility and function. We conclude that the AHR complex integrates ligand binding and cyclic nucleotide signaling to generate an adequate transcriptional response.
Type of material: Journal Article
Publisher: Elsevier
Journal: Biochemical Pharmacology
Volume: 77
Issue: 4
Start page: 723
End page: 733
Copyright (published version): 2008 Elsevier
Keywords: ARA9AIPPDEcAMPcGMPDioxin
DOI: 10.1016/j.bcp.2008.08.027
Language: en
Status of Item: Peer reviewed
Appears in Collections:Medicine Research Collection

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