Imaging the genetics of executive functions

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Title: Imaging the genetics of executive functions
Authors: Greene, Ciara M.
Braet, Wouter
Johnson, Katherine A.
Bellgrove, Mark A.
Permanent link: http://hdl.handle.net/10197/6121
Date: Sep-2008
Abstract: Recent advances in neuroimaging technologies have allowed ever more detailed studies of the human brain. The combination of neuroimaging techniques with genetics may provide a more sensitive measure of the influence of genetic variants on cognitive function than behavioural measures alone. Here we present a review of functional magnetic resonance imaging (fMRI) studies of genetic links to executive functions, focusing on sustained attention, working memory and response inhibition. In addition to studies in the normal population, we also address findings from three clinical populations: schizophrenia, ADHD and autism spectrum disorders. While the findings in the populations studied do not always converge, they all point to the usefulness of neuroimaging techniques such as fMRI as potential endophenotypes for parsing the genetic aetiology of executive function.
Funding Details: Health Research Board
Science Foundation Ireland
Type of material: Journal Article
Publisher: Elsevier
Copyright (published version): 2007 Elsevier
Keywords: Neuroimaging;Executive functions;Dopamine;Genetics
DOI: 10.1016/j.biopsycho.2007.11.009
Language: en
Status of Item: Peer reviewed
Appears in Collections:Psychology Research Collection

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