Noradrenergic genotype predicts lapses in sustained attention

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Title: Noradrenergic genotype predicts lapses in sustained attention
Authors: Greene, Ciara M.
Bellgrove, Mark A.
Gill, Michael
Robertson, Ian H.
Permanent link: http://hdl.handle.net/10197/6316
Date: Jan-2009
Abstract: Sustained attention is modulated by the neurotransmitter noradrenaline. The balance of dopamine and noradrenaline in the cortex is controlled by the DBH gene. The principal variant in this gene is a C/T change at position −1021, and the T allele at this locus is hypothesised to result in a slower rate of dopamine to noradrenaline conversion than the C allele. Two hundred participants who were genotyped for the DBH C−1021T marker performed the Sustained Attention to Response Task (SART). DBH genotype was found to significantly predict performance; participants with more copies of the T allele made more errors of commission, indicative of lapses in sustained attention. A significant negative correlation was also observed for all participants between errors of commission and mean reaction time. The decrease in noradrenaline occasioned by the T allele may impair sustained attention by reducing participants’ ability to remain alert throughout the task and by increasing their susceptibility to distractors.
Type of material: Journal Article
Publisher: Elsevier
Copyright (published version): 2008 Elsevier
Keywords: Sustained attention;DBH;Noradrenaline
DOI: 10.1016/j.neuropsychologia.2008.10.003
Language: en
Status of Item: Peer reviewed
Appears in Collections:Psychology Research Collection

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