Noradrenergic genotype predicts lapses in sustained attention

DC FieldValueLanguage
dc.contributor.authorGreene, Ciara M.-
dc.contributor.authorBellgrove, Mark A.-
dc.contributor.authorGill, Michael-
dc.contributor.authorRobertson, Ian H.-
dc.date.accessioned2015-01-21T10:14:16Z-
dc.date.available2015-01-21T10:14:16Z-
dc.date.copyright2008 Elsevieren
dc.date.issued2009-01-
dc.identifier.citationNeuropsychologiaen
dc.identifier.urihttp://hdl.handle.net/10197/6316-
dc.description.abstractSustained attention is modulated by the neurotransmitter noradrenaline. The balance of dopamine and noradrenaline in the cortex is controlled by the DBH gene. The principal variant in this gene is a C/T change at position −1021, and the T allele at this locus is hypothesised to result in a slower rate of dopamine to noradrenaline conversion than the C allele. Two hundred participants who were genotyped for the DBH C−1021T marker performed the Sustained Attention to Response Task (SART). DBH genotype was found to significantly predict performance; participants with more copies of the T allele made more errors of commission, indicative of lapses in sustained attention. A significant negative correlation was also observed for all participants between errors of commission and mean reaction time. The decrease in noradrenaline occasioned by the T allele may impair sustained attention by reducing participants’ ability to remain alert throughout the task and by increasing their susceptibility to distractors.en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsThis is the author’s version of a work that was accepted for publication in Neuropsychologia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neuropsychologia (VOL 47, ISSUE 2, (2009)) DOI: 10.1016/j.neuropsychologia.2008.10.003en
dc.subjectSustained attentionen
dc.subjectDBHen
dc.subjectNoradrenalineen
dc.titleNoradrenergic genotype predicts lapses in sustained attentionen
dc.typeJournal Articleen
dc.internal.authorcontactotherciara.greene@ucd.ie-
dc.internal.availabilityFull text availableen
dc.statusPeer revieweden
dc.identifier.volume47en
dc.identifier.issue2en
dc.identifier.startpage591en
dc.identifier.endpage594en
dc.identifier.doi10.1016/j.neuropsychologia.2008.10.003-
dc.neeo.contributorGreene|Ciara M.|aut|-
dc.neeo.contributorBellgrove|Mark A.|aut|-
dc.neeo.contributorGill|Michael|aut|-
dc.neeo.contributorRobertson|Ian H.|aut|-
dc.internal.rmsid437127470-
dc.date.updated2014-10-26T15:54:17Z-
item.grantfulltextopen-
item.fulltextWith Fulltext-
Appears in Collections:Psychology Research Collection
Files in This Item:
File Description SizeFormat 
11._Greene_noradrenergic_genotype_NeuroImage.pdf503.04 kBAdobe PDFDownload
Show simple item record

SCOPUSTM   
Citations 5

55
Last Week
0
Last month
checked on Mar 14, 2019

Google ScholarTM

Check

Altmetric


This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. For other possible restrictions on use please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.