Transfer Hydrogenation of Ketones and Activated Olefins Using Chelating NHC Ruthenium Complexes
|Title:||Transfer Hydrogenation of Ketones and Activated Olefins Using Chelating NHC Ruthenium Complexes||Authors:||Horn, Sabine
|Permanent link:||http://hdl.handle.net/10197/6570||Date:||Jun-2011||Abstract:||N-Heterocyclic carbene (NHC) ruthenium complexes consisting of different donor substituents attached to the NHC ligand efficiently catalyse the transfer hydrogenation of ketones and of activated olefins in α,β-unsaturated ketones to give saturated alcohols. The most active catalyst precursor contains a tethered olefin as a hemilabile donor site. This complex also converts nitriles and, depending on the reaction conditions, either benzylamines are produced by means of transfer hydrogenation, or amides from formal addition of H2O. Kinetic analysis of the double hydrogenation of α,β-unsaturated ketones indicates fast isomerisation of the enol intermediate to its saturated ketone tautomer prior to the second hydrogenation.||Funding Details:||European Research Council||Type of material:||Journal Article||Publisher:||Wiley||Journal:||European Journal of Inorganic Chemistry||Volume:||2011||Issue:||18||Start page:||2863||End page:||2868||Copyright (published version):||2011 Wiley||Keywords:||Ruthenium; N-Heterocyclic carbene; Hydrogenation; Transfer hydrogenation; Ketones; Chemoselectivity; Asymmetric transfer hydrogenation; Enantioselective transfer hydrogenation; Highly efficient catalysts; Carbonyl-compounds; Carbene complexes; Allylic alcohols; Base hydrolysis; Mechanistic aspects; Iridium complexes; Polar bonds||DOI:||10.1002/ejic.201100143||Language:||en||Status of Item:||Peer reviewed|
|Appears in Collections:||Chemistry Research Collection|
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