Thiol redox homeostasis in neurodegenerative disease

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Title: Thiol redox homeostasis in neurodegenerative disease
Authors: McBean, Gethin J.
Aslan, Mutay
Griffiths, Helen R.
Torrão, Rita C.
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Date: Aug-2015
Abstract: This review provides an overview of the biochemistry of thiol redox couples and the significance of thiol redox homeostasis in neurodegenerative disease. The discussion is centred on cysteine/cystine redox balance, the significance of the xc− cystine–glutamate exchanger and the association between protein thiol redox balance and neurodegeneration, with particular reference to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and glaucoma. The role of thiol disulphide oxidoreductases in providing neuroprotection is also discussed.
Type of material: Journal Article
Publisher: Elsevier
Journal: Redox Biology
Volume: 5
Start page: 186
End page: 194
Copyright (published version): 2015 the Authors
Keywords: CysteineGlutathioneThioredoxinGlutaredoxinPeroxiredoxinNeurodegenerative disease
DOI: 10.1016/j.redox.2015.04.004
Language: en
Status of Item: Peer reviewed 2015-06-22T11:24:05Z
Appears in Collections:Biomolecular and Biomedical Science Research Collection

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