Methyltransferase Activity of an Iridium Center with Methylpyridinium as Methylene Source

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Title: Methyltransferase Activity of an Iridium Center with Methylpyridinium as Methylene Source
Authors: Lalrempuia, Ralte
Müller-Bunz, Helge
Albrecht, Martin
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Date: 10-Oct-2011
Online since: 2015-08-20T16:05:26Z
Abstract: An iridium center transfers a methyl group from pyridinium to an aryl unit, using exclusively the pyridine-bound methyl group as a mild methylene source. The reaction also involves cleavage of an unactivated C(aryl)[BOND]H bond and nitrile solvent activation. The process is reminiscent of DNA methylation and entails the formation of two new C(sp2)[BOND]C(sp3) bonds within the metal coordination sphere (see scheme).
Funding Details: European Research Council
Science Foundation Ireland
Type of material: Journal Article
Publisher: Wiley
Journal: Angewandte Chemie International Edition
Volume: 50
Issue: 42
Start page: 9969
End page: 9972
Copyright (published version): 2011 Wiley
Keywords: Functional analoguesIridiumMethyl transferaseMethylene transferPyridinium
DOI: 10.1002/anie.201104073
Language: en
Status of Item: Peer reviewed
Appears in Collections:Chemistry Research Collection

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